Non-gravitational fluid delivery device for ophthalmic applications

ABSTRACT

A fluid dispensing device includes a cartridge comprising a housing and a head coupled to the housing. The housing forms a first chamber configured to accommodate a fluid; and the head includes a nozzle; and an elastomeric wall that is spaced from the nozzle to form a holding chamber. The holding chamber is in fluid communication with the first chamber and configured to accommodate a portion of the fluid; and the nozzle forms one or more openings to eject the portion of the fluid from the holding chamber. The one or more openings form an oblong shape such that a length of the oblong shape is greater than a width of the oblong shape. The one or more openings can include two parallel slots that together form the oblong shape.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. application Ser. No.15/931,482, filed May 13, 2020, which claims the benefit of the filingdate of, and priority to, U.S. Provisional Application No. 62/847,693,filed May 14, 2019, and U.S. Provisional Application No. 63/024,373,filed May 13, 2020, the entire disclosures of which are incorporatedherein by reference.

TECHNICAL FIELD

The present disclosure relates in general to a device to deliverophthalmic drugs to an eye of a user. The device allows for thenon-gravitational delivery of viscous ophthalmic drugs to the eye usingone or more micro-streams.

BACKGROUND

Many eye-drop medications and artificial tear formulations withincreased formulation viscosity (e.g., 50 centipoise (cps) to 200 cps)have been shown to have longer residence time, better mucosal adhesion(adhesion to mucin cells), and improved corneal hydration. This isimportant for dry eye diseases but also important for other drugdelivery applications where higher concentrations and longer residencetime improve drug delivery efficacy.

Dispensing higher viscosity fluids (e.g., fluids having a viscosity ofbetween 50 cps to 200 cps) from a conventional eye dropper is not idealfor a number of reasons. First, the dose volume for a conventional eyedropper varies. The dose volume can range anywhere from 30 to 65 μL,with a repeatability of about +/−5 μL or about +/−10% of standarddeviation. The tilt angle range, which people use during applicationusing a conventional eye dropper, can have a measurable impact on dropvolume by up to an additional 10%. To account for partial misses offluid delivery to the eye, an excess of fluid is typically delivered tothe eye using a conventional eye dropper. When the dose volume variesand there is an excess fluid applied to the eye, the excess fluidsometimes takes several minutes to drain from the eye, which cantemporarily lead to a non-uniform tear layer that causes blurring due tospherical and comb aberrations. A further nuisance is that sometimes theexcess viscous drop volume partially misses the eye during applicationand then gets stuck in the eyelashes, which leads to crusting as thedrop dries out.

Second, the shape and size of a drop resulting from a conventional eyedropper results in reduced uniform spreading of the drop over the eye.Generally, a conventional shape and size of a 50 μL drop resulting froma conventional eye dropper is a semi-sphere having a diameterapproximately 5 mm. When a 5 mm diameter sphere contacts the eye, thereis approximately about 2 mm of margin on either side of the drop betweenthe drop and the eyelid. As such, it is often difficult to hit the eyewithout a portion of the drop landing or splashing outside of the eye.When the drop is of a highly viscous fluid, the drop that hits thecorneal surface can be approximately 2-3 mm in height as measured normalto the surface of the cornea. The wiping action of the human eyelid doesnot do well to force the uniform spreading of such a tall perturbationgiven the eyelid itself is only approximately 3-4 mm thick. As such,uniform spreading becomes more challenging with high viscosityformulations.

Accordingly, for high viscosity formulations, it is preferred todispense smaller, uniform doses across the eye and allow the eyelids tospread the small drops uniformly in the vertical direction (e.g.,between eyelids). Using smaller doses reduces or eliminates problemsassociated with short term blurring and can allow for even higherviscosity formulations that are more effective in terms of theirresidency time and moisture retention, and therefore, are more pleasingto the end user.

Moreover, with conventional reusable eye drop systems, preservatives areoften included in the dispensed fluid to prevent the growth of bacterialor viral germs. These preservatives may result in damage and cornealsensitization over time for those people that regularly use the drops.While a filter may be used to reject the preservative before it reachesthe eye of the user, the filter may not be applicable to all types offluids/formulations. Reusable eye drop systems that do not includepreservatives often require built-in filters and unidirectional valves,but this is complex and adds significant cost to the packaging of thereusable eye drop system.

Finally, conventional reusable eye drop systems do not remind the userto take eye drop medication, help the user efficiently guide eye dropseffectively into their eyes without blink interference, and verify theuser is taking the medication at the prescribed dosage.

Thus, a system for applying smaller viscous drop sizes evenly across theeye with a horizontal non-gravitational delivery and sterilizationcapability that also reminds the user to take eye drop medication, helpsthe user efficiently guide eye drops effectively into their eyes withoutblink interference, and verifies the user is taking the medication atthe prescribed dosage is needed.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a perspective view of an example non-gravitational fluiddelivery device in accordance with at least one embodiment of thepresent disclosure, the non-gravitational fluid delivery device systemincluding a cartridge housed within an applicator.

FIG. 2 is a perspective view of the cartridge of FIG. 1 , in accordancewith at least one embodiment of the present disclosure.

FIG. 3 is a perspective cutaway view of the cartridge of FIG. 1 , inaccordance with at least one embodiment of the present disclosure.

FIG. 4 is a perspective view of a portion of the cartridge of FIG. 1 ,in accordance with at least one embodiment of the present disclosure.

FIG. 5 is another perspective view of the cartridge of FIG. 1 , inaccordance with at least one embodiment of the present disclosure.

FIG. 6 is a cross-sectional view of a portion of the cartridge of FIG. 1, in accordance with at least one embodiment of the present disclosure.

FIG. 7 is a perspective cutaway view of a portion of the cartridge ofFIG. 1 , in accordance with at least one embodiment of the presentdisclosure, the portion of the cartridge of FIG. 1 including a nozzlehaving openings.

FIG. 8 is a diagrammatic perspective view of an eye, in accordance withan embodiment of the present disclosure.

FIG. 9A is a diagrammatic of the opening(s) of the nozzle and resultingdrop shapes, according to an example embodiment.

FIG. 9B is a diagrammatic of the opening(s) of the nozzle and resultingdrop shape, according to another example embodiment.

FIG. 10 is a diagrammatic illustration of the opening of the nozzle ofFIG. 9B and a resulting drop footprint, in accordance with anotherembodiment of the present disclosure.

FIG. 11 is a diagrammatic illustration of the opening of FIG. 9B and aresulting drop footprint, in accordance with another embodiment of thepresent disclosure.

FIG. 12 is a diagrammatic illustration of the opening of FIG. 9B and aresulting drop footprint, in accordance with another embodiment of thepresent disclosure.

FIG. 13 is a perspective view of the cartridge of FIG. 1 , in accordancewith another embodiment of the present disclosure.

FIG. 14 is a cross-sectional view of the cartridge of FIG. 13 , inaccordance with at least one embodiment of the present disclosure.

FIG. 15 is a diagrammatic illustration of a cradle, the applicator ofFIG. 1 , and a controller, the applicator including a sterilizer and ablink detector.

FIG. 16 is a perspective view of the applicator of FIG. 1 , inaccordance with at least one embodiment of the present disclosure.

FIG. 17 is a diagrammatic illustration of the blink detector of FIG. 15and an eye, in accordance with at least one embodiment of the presentdisclosure.

FIG. 18 is another diagrammatic illustration of the blink detector ofFIG. 16 and the eye, in accordance with at least one embodiment of thepresent disclosure.

FIG. 19 is yet another diagrammatic illustration of the blink detectorof FIG. 16 and the eye, in accordance with at least one embodiment ofthe present disclosure.

FIG. 20 is a graphical illustration of timelines of a blink detectionsignal that show overlapping signal traces for comparison that representdifferent conditions including baseline noise far away from the eye, ahigher-level signal near the eye, and a transient spiked signalrepresenting a blink event in accordance with at least one embodiment ofthe present disclosure.

FIG. 21 is a cross-sectional view of a portion of the device of FIG. 1 ,in accordance with at least one embodiment of the present disclosure.

FIG. 22 is a perspective cutaway view of the cartridge and theapplicator of FIG. 1 , in accordance with at least one embodiment of thepresent disclosure.

FIG. 23 is a diagrammatic illustration of the applicator and thecartridge of FIG. 1 , in accordance with at least one embodiment of thepresent disclosure.

FIG. 24 is a flow chart illustration of a method of operating the deviceof FIG. 1 , according to an example embodiment.

FIG. 25A is a perspective cutaway view of the cartridge of FIG. 1 duringa step of the method of FIG. 24 , in accordance with an embodiment ofthe present disclosure.

FIG. 25B is a perspective cutaway view of the cartridge of FIG. 1 duringanother step of the method of FIG. 24 , in accordance with an embodimentof the present disclosure.

FIG. 25C is a perspective cutaway view of the cartridge of FIG. 1 duringanother step of the method of FIG. 24 , in accordance with an embodimentof the present disclosure.

FIG. 25D is a perspective cutaway view of the cartridge of FIG. 1 duringanother step of the method of FIG. 24 , in accordance with an embodimentof the present disclosure.

FIG. 26 is a perspective view of the cartridge of FIG. 1 , in accordancewith yet another embodiment of the present disclosure.

FIG. 27 is a perspective cutaway view of the cartridge of FIG. 26 , inaccordance with another embodiment of the present disclosure.

FIG. 28 is a cross-sectional view of a portion of the cartridge of FIG.26 , in accordance with another embodiment of the present disclosure.

FIG. 29 is another perspective cutaway view of the cartridge of FIG. 26, in accordance with another embodiment of the present disclosure.

FIG. 30 is a diagrammatic illustration of the opening of the cartridgeof FIG. 26 , in accordance with an embodiment of the present disclosure.

FIG. 31 is a diagrammatic illustration of the opening of the cartridgeof FIG. 26 , in accordance with another embodiment of the presentdisclosure.

FIG. 32 is a perspective view of the cartridge of FIG. 26 and the blinkdetector and sterilizer of FIG. 16 , in accordance with at least oneembodiment of the present disclosure.

FIG. 33 is a perspective cutaway view of the cartridge of FIG. 26 andthe sterilizer of FIG. 16 , in accordance with at least one embodimentof the present disclosure.

FIG. 34 is a diagrammatic illustration of a node for implementing one ormore example embodiments of the present disclosure, according to anexample embodiment.

DETAILED DESCRIPTION

Disclosed herein is one example of a non-gravitational dropper deviceand/or sprayer device that delivers a fluid to a patient or user.However, neither the term “spray”, “sprayer”, “drop”, or “dropper” arelimiting, as the fluid that is dispersed from the device may beconsidered a “stream”, “micro-stream”, or “sheet” of fluid. Generally,the fluid dispersed from the device includes a pulsed continuous streamof liquid. Generally, the device delivers a fluid to the eye of apatient, but the device could be used for other applications, such as todeliver viscous fluid medications to the nose or mouth in otherapplications. In one embodiment, the device is configured to deliver aviscous ophthalmic drug to the eye of the patient via a nozzle with anarray of openings forming an oblong shape or a slit-like opening formingan oblong shape such that the delivery of the fluid via the nozzleresults in an oblong application of the fluid across a horizontalportion of the eye, which improves the application of the fluid to theeye. Generally, the delivery of the fluid via the array of openingsallows for multiple droplet streams with extended tails to contact theeye, with the streams contacting different locations in the eye.

FIG. 1 illustrates an embodiment of a fluid delivery device that isreferenced and designated by the numeral 10. In some embodiments, thedevice 10 includes an applicator 15 and a cartridge 20 that is removablypositioned within the applicator 15.

FIG. 2 illustrates an embodiment of the cartridge 20. As illustrated,the cartridge 20 includes a housing 30 and a head 35 that is attached tothe housing 30. In some embodiments, the cartridge 20 is about 14 mmwide×14 mm long×7 mm thick, however, the dimensions may vary.

Generally, and as illustrated in the cutaway view in FIG. 3 , thehousing 30 is a fluid reservoir or forms a chamber 40 in which a viscousdrug or viscous fluid (not illustrated in FIG. 3 ) is accommodated. Insome embodiments, the viscous fluid is aseptically dispensed before thehead 35 is heat sealed or coupled to the housing 30. In someembodiments, the housing 30 is a blow-fill-seal package container.

As illustrated, the head 35 is coupled to the housing 30 to dispense theviscous fluid from the chamber 40. Generally, the head 35 is at leasttemporarily in fluid communication with the chamber 40 and forms anozzle 37 and an air entry port 45. The head 35 also includes a cap 50and a wall 55 that is movable relative to the nozzle 37. The head 35forms a holding chamber 62 that is in fluid communication with thechamber 40 and that is positioned between the nozzle 37 and the wall 55.In some embodiments, the air entry port 45 is positioned between thenozzle 37 and the housing 30 as illustrated in FIGS. 3 and 4 . In someembodiments, the air entry port 45 is a sterile air filtered air entryport. A filter 65 may be positioned over the air entry port 45. In someembodiments, the filter 65 is made from polypropylene porous materialwith 0.1 μm-0.2 μm passages. The filter 65 can be welded directly to thehead 35 when the head 35 is also molded from polypropylene. In someembodiments, the wall 55 is a membrane or elastomeric wall that is“squeezable” or flexible enough to deform in response to a strikingforce being applied to the wall 55.

FIG. 5 is a perspective view of the device 10 and illustrates anembodiment of the head 35 in which the nozzle 37 is positioned betweenthe air entry port 45 and the housing 30. In some embodiments, the cap50 protects the air entry port 45 from debris during loading of thecartridge 20 into the applicator 15. In some embodiments, the air entryport 45 is on the opposite size of the nozzle 37 (illustrated in FIGS.26 and 27 ).

FIG. 6 is a partial cross-sectional view of the head 35. As illustrated,a valve 70 is formed or positioned within the head 35 such that whendirect mechanical impact occurs on the wall 55, which induces positivedisplacement that ejects fluid from the nozzle 37, the valve 70 is movedinto a closed position such that the fluid does not return from the head35 into the chamber 40. One example valve 70 includes an arm 75 that iscoupled to the wall 55 such that movement of the wall 55 also moves thearm 75. Downward movement of the wall 55 moves the arm 75 across apassage 80 that extends between the chamber 40 and the head 35. As such,the arm 75 fluidically isolates the holding chamber 62 from the chamber40, thus making the nozzle 37 the only outlet for the fluid. The arm 75and the passage 80 are only one example of the valve 70 and may bereplaced with many different examples of elastomeric one-way valves.

FIG. 7 is a partial perspective cutaway view of one embodiment of thehead 35. As illustrated, the nozzle 37 includes an array of openings 85.In some embodiments, the cap 50 and the wall 55 are coupled together orformed together. Generally, the purpose of the wall 55 is to facilitateeasy squeeze out of the fluid through the nozzle 37 and to allow easyself-contained capping of the nozzle 37, via the cap 50, after a jettingevent. FIG. 7 also illustrates a conical shape of each opening in thearray of openings 85. As illustrated, an opening 90 of the array ofopenings 85 includes a conical shape as it extends through a wall 95 ofthe nozzle 37. That is, an opening 100 in the interior surface 105 ofthe head 35 is larger than an opening 110 in the exterior surface 115 ofthe head 35.

Generally, a target diameter D of the opening 110 is based on the liquidviscosity, delivery speed, surface tension, and density of the fluid tobe dispersed. Generally, the target diameter D must be large enough toovercome hydraulic losses from the viscous force, but small enough thatthe stream, or ejection of fluid, will pinch off into a single drop dueto surface tension forces. In some embodiments, the target slit width ordiameter of a nozzle is 100-300 microns, a delivery speed isapproximately 1.5-3 meters/second (m/s), liquid viscosity (μ) is betweenabout 1 cp-500 cp, surface tension (σ) is between about 40-72 dynes/cm,and density (ρ) is approximately that of water or about 1 gm/cc.Generally, the ejection velocity or speed needs to be low enough so asto be well tolerated in terms of the eye sensation, but high enough totraverse the target distances between 10-25 mm without beingsubstantially deflected by gravity or cross winds. Speeds below 3 m/sare much lower and a small fraction of the speed of raindrops, gentleshower heads, eye washes, and established regulations for water jetspeeds at water parks and for toy water guns. Speeds above 1 m/s ensureonly a sub millimeter deflection due to gravity of the nozzle aim overaiming distances up to 20 mm. In some embodiments, 1.5 m/s is an optimalspeed, but with some viscous materials, the initial velocity maydecrease over the trajectory due to the viscous drag of the microstreamtail such that initial ejection speeds of 3 m/s are more ideal asvelocity on impact to the eye is lower. The optimal nozzle diameter D isbetween 100-300 μm, with the exact dimension depending upon theinfluence of nozzle surface tension, viscosity of the medium, volume ofejected fluid, and sensitivity to contamination. Target volume may be aslow as 8 μL to be fully effective, as this value is approximately themaximum amount of tear fluid an eye can hold without immediate drainage.Volumes in the range of 10 μL-15 μL are more ideal to account for somepossibilities for loss. Generally, openings having circular shapesrequire diameters of 100-300 μms.

FIG. 8 illustrates an array of microdroplets 120 on an eye 125 afterthey have been delivered through the nozzle 37 of the device 10 fromFIG. 1 . The array 120 generally defines a width 120 a and a height 120b. As illustrated, the array 120 is composed of small spherical droplets120 c. As the array of openings 85 is arranged linearly on one axis, thelinear arrangement of the openings 85 results in the oblong shape of thearray of microdroplets 120 when collectively merged together. The eye125 includes an upper eyelid 130 and a lower eyelid 135 and, whenopened, exposes a surface of the eye 125 that has a dimension 140measured—in the same direction as the height 120 b—between the upper andlower eyelids 130 and 135. Generally, the exposed cornea and scleraregions are elliptical in shape. Due to the height 120 b relative to thedimension 140, a clearance 145 is formed between the array of themicrodroplets 120 and the upper eyelid 130, and a clearance 150 isformed between the array of microdroplets 120 and the lower eyelid 135.The array of microdroplets 120 allows for a more uniform delivery offluid in the horizontal direction (i.e., the direction in which thewidth 120 a of the array 120 is measured in FIG. 8 ) across the cornea.The uniform spreading of these microdroplets in the vertical direction(i.e., the direction in which the height 120 b of the array 120 ismeasured in FIG. 8 ) is facilitated quickly after a few blinks of theeyelids 130 and 135, which act like windshield wipers across the surfaceof the eye 125. FIG. 8 also illustrates a conventional droplet 151 andits size compared to the array of microdroplets 120.

In practice, viscous fluids above 100 cps typically have a “tail” uponejection because the stream fails to quickly pinch off, due to surfacetension, or separate from the nozzle 37. FIG. 9A illustrates fluidstreams 151 that are formed by a nozzle having the plurality of circularopenings 85. As illustrated, each of the fluid streams has a “tail”portion 152 that, in some embodiments, never detach from the nozzle 37and at least a small portion of the tail remains on the nozzle 37 asresidue. In some embodiments, each of the streams coalesce into a singlemicrostream after exiting the nozzle 37. However, the number of tailsformed using the plurality of circular openings 85 can lead to excesswaste or contamination. When the plurality of openings 85 are arrangedin a horizontal or linear array to form an oblong shape, typically thestreams have some overlap by the time they reach the eye 125 and form acontinuous oval-like film very similar in shape to the oval eye openingbetween the eyelids. The micro-stream formed is stable to air flow. Insome embodiments, dust or debris may clog one or more openings as thesize of each opening is small (e.g., 100-200 μm).

In some embodiments and as illustrated in FIG. 9B, the nozzle 37includes an oval or stadium shaped opening 160 in the nozzle 37, whichfacilitates pinch off while preserving the cross-sectional area and thusgenerally maintaining or reducing the cross-sectional impedance forflow. As illustrated, generally one microstream 161 having one tailportion 162 is formed by the opening 160. When each tail portionpotentially creates residue on the nozzle 37, reducing the number oftail portions created in each ejection reduces the volume of residueremaining on the nozzle 37 after each ejection. As such, the nozzle 37including one linearly extended opening 160 may reduce the volume ofresidue when compared to the volume ejected as compared to a nozzle 37having three or more circular openings. For example, instead of having anozzle 37 with openings having a 300 μm diameter, the nozzle 37 caninclude only one opening that is 200 μm×8000 μm (8 mm) along thelongitudinal axis. In some embodiments, a slit-like opening has a moreactive ejection area than the plurality of openings 85, and therefore,an actuation energy needed to deliver the fluid is reduced. Moreover, aslit-like opening allows for a micro-stream to coalesce quicker than theplurality of openings 85, and thus, forms a much more targeted deliveryof liquid less much less susceptible to external air currents. As such,instead of having the plurality of openings 85 as illustrated in FIG. 7, in some embodiments the nozzle 37 includes one opening that forms aribbon shaped “sheet” micro-stream instead of a cylindrically shapedmicro-stream. This “sheet” like micro-stream is therefore advantageousin some embodiments. For example, and as illustrated in FIG. 10 , theplurality of openings 85 may be omitted and one opening 160 is formed inthe nozzle 37. As illustrated, the opening 160 has a length much greaterthan a width and thus forms an oblong shape. The drop footprint 165associated with the opening 160 is also illustrated in FIG. 10 . Asillustrated, the opening 160 is a stadium shape. The tail end eventuallyforms a single viscous tail much smaller than the nozzle 37, and thusdramatically reduces or eliminates residue. The degree to which break upof this liquid micro sheet is reproducible at the tail end of the jet isextremely complex and is affected by lateral airflow, small nozzle shapedefects, entrainment of air bubbles at the nozzle exit, or smallperturbations due to surface debris. These instabilities arise from asimple thin walled liquid stream and the mathematics characterizing andsimulating this behavior is very complex. Regardless, the viscous fluidthat is dispersed from the opening 160 generally results in a sheetforming a single tail that is opposite the head of the sheet. In someembodiments, the length of the slit or opening 160 is unlimited and caneven be 12 mm long as an example, but the width of the slit requiresslightly smaller dimensions typically between 100-250 microns.

In some embodiments and as illustrated in FIG. 11 , the nozzle includesone opening 170 that has an undulating surface to form an undulatingstadium shape. When the opening 170 includes an undulating opening,which is configured to match the typical natural spatial frequency owingto air related capillary surface tension instability distances, the tailjetting reproducibility and uniformity can be improved by forcingnaturally instabilities to consistently occur, and therefore, be morepredictable while at the same time not impacting the overall shapeuniformity of the main mass of the micro-stream drop at its head. Thedrop footprint 175 associated with the opening 170 is also illustratedin FIG. 11 . As illustrated in FIG. 11 , the generally stadium shape isformed with an undulating surface, but the shape is not limited to thegenerally stadium shape. For example, the general shape may include abow-tie shape, a rectangular shape, and the like to improve the tailjetting reproducibility and uniformity of the fluid sheet dispersed fromthe opening 170. In some embodiments, an undulating surface is definedas a surface having a sinuous or wavelike form. As such, an undulatingsurface generally has alternating positive and negative radiuses ofcurvature.

In some embodiments and as illustrated in FIG. 12 , the plurality ofopenings 85 may be omitted and one opening 180 is formed in the nozzle37. The drop footprint 185 associated with the opening 180 is alsoillustrated in FIG. 12 . As illustrated, the opening 180 forms a bow-tieshape and has a length 180 a, a max width 180 b, and a minimum width 180c. Because the widths 180 b and 180 c are small, the ability to pinchoff the tail of the drop at the exit of the nozzle 37 is improved.Moreover, because the “sheet” stream that exits the opening 180 isinitially connected, inertial forces are larger and provide astabilizing dynamic which overcomes small amounts of nozzlemanufacturing defects or debris and air perturbations. In someembodiments and with the bow-tie shape opening 180, the impedance tojetting at the edge of the slit can be slightly lessened relative to thecenter, thus creating a more uniform edge profile. Finally, the bow-tieshape delays the coalescence of the “sheet-like” micro-stream into amore cylindrical stream due to surface tension instabilities. By tuningthe shape of the nozzle, impact over the eye can generally match theshape of the eye.

FIGS. 13-14 illustrate another embodiment of the head 35 designated withthe reference numeral 190. In some embodiments, the head 190 includes awicking capillary tube 195 that places the chamber 40 in fluidcommunication with the holding chamber 62. In some embodiments, thewicking capillary tube 195 does not extend into the holding chamber 62,as it would dampen the fluid ejection. However, the capillary tube 195helps wick fluid into the holding chamber 62 and acts as mechanicalimpedance channel, which prevents back flow during a rapid mechanicalstrike of the wall 55. In some embodiments and when the array ofopenings 85 is capped before the wall 55 is released from a downwardstriking position, the wall 55 will provide suction that draws upmaterial through the capillary tube 195 as it returns to its normalposition.

The capillary tube 195 may be replaced with a capillary wicking materialthat provides flow independent of gravity. Typical medical gradecapillary wick materials are PET, glycol-modified PET (PETG), orPolyurethane foams made by many different vendors such as Porex,Aquazone® by FXI, PureSorb® by Berkshire, or Capu-Cell® by FoamSciences.

In some embodiments, the interior surfaces that define the holdingchamber 62 have high surface energy materials evaporated on them tofacilitate the flow of liquids into the holding chamber 62 and to helpprevent the occurrence of trapped bubbles. In some embodiments, airbubble channels 200 are formed in the head 35 and are hydrophobic butthe holding chamber 62 is hydrophilic, so the air can escape to theedges and the fluid will fill up the holding chamber 62.

In some embodiments, the head 35 also includes walls 205 and 210 thatare not connected to the wall 55, but force flow in one direction andedge walls 215 and 220 that tip down to be more compliant. The result isa geometry that is more uniform to flow along the cross section, asillustrated in FIG. 14 . The walls 205, 210, 215, and 220 overcomeissues with edge nozzle ejection defects from the deformation of thewall 55 being pinned to a hard edge of the head 35.

In some embodiments, a hydrophilic coating is disposed on the interiorsurface of the nozzle 37 that ejects the fluid and a Teflon orTeflon-like (e.g., with C-F3 side chain groups) on the exterior surfaceof the nozzle 37 to reduce leakage from contamination as well as improveuniformity between stream breakups.

FIG. 15 is a diagrammatic illustration of the applicator 15, a remotedevice 250, and a cradle 255 that accommodates the applicator 15 all ofwhich are in communication via a network 260. As illustrated, the cradle255 includes a transmitter 265, a power source 270, and a controller275. In some embodiments, the applicator 15 includes a transmitter 280,a power source 285, a controller 290, a blink detector 295, a sterilizer300, and a trigger 305. In some embodiments, the controller 290 isoperably coupled to the blink detector 295, the power source 285, thetransmitter 280, the sterilizer 300, and the trigger 305.

Referring to FIG. 16 , the applicator 15 includes a housing 310, a cap315 coupled to and movable relative to the housing 310, a mechanicalactivation button 320 coupled to a mechanism for opening a dust cover325 (illustrated in FIG. 23 ) and for waking up and arming the device 10for usage. In some embodiments, the applicator 15 includes the slidingdust cover 325, which extends over or across an opening 326 that allowsthe fluid to exit the housing 310 after exiting the nozzle 37 of theinternal cartridge 20. The housing 310 is sized to accommodate thecartridge 20, the transmitter 280, the power source 285, the controller290, the blink detector 295, the sterilizer 300, and the trigger 305. Insome embodiments, the applicator 15 is an “intelligent” applicator 15that allows for added user convenience such as horizontalnon-gravitational spray, visual aiming LEDs, blink detection sensors andtriggered dispense upon eyelid opening, as well as full cloudconnectivity for compliance monitoring. Because the applicator 15 can beused over and over with replaceable cartridges, the cost to a user isvery low and amortized to virtually zero in the case of a long-termuser, such as a glaucoma patient.

Turning to FIGS. 17-19 , an electronic alignment check before or duringdrug delivery is ideal to align the nozzle 37 with the eye 125. In someembodiments, the blink detector 295 includes one or more reflectiveoptical proximity infrared sensors to detect the face/eye being withinfiring range. In other embodiments, the detector 295 checks for blinkingto make sure the drug is not dispensed during a blink but shortly uponopening of the eyelids. In some embodiments, the applicator 15 dispensesfluid 345 after a predetermined period of time after a blink event hasbeen detected or upon opening of the eyelids at the tail end of theblink detection event.

In some embodiments and as illustrated in FIGS. 17-19 , the blinkdetector 295 includes two reflective proximity sensors 350 and 355 in apaired arrangement to verify proper eye targeting and to detect eyeblinks. In some embodiments, sensors 350 and 355 are positioned oneither side of the nozzle 37. In some embodiments, each sensor 355 and350 includes both a LED and photodiode (illustrated as 355 a and 355 bin FIG. 19 ). In some embodiments, the two sensors 350 and 355 areoptical proximity infrared sensors that are configured to detect thepresence of the eye 125 and determine if a blink has occurred. In someembodiments, the sensors 350 and 355 are reflective proximity sensorswith lensed light collection and surface mount technology packaging. Insome embodiments, the sensors 350 and 355 are OPB733TR sensors from TTElectronics of Carrollton, Tex., United States of America or HSDL-9100sensors from Avago Technologies of San Jose, Calif., United States ofAmerica, but the sensors 350 and 355 may be any LED and photodiodedetector. In some embodiments, the sensors 350 and 355 have a moldedpackage surface above the top surfaces of their micro lenses so as toprovide a convenient surface onto which a micro prism of approximately30 degrees angle can be mounted. Generally, the sensors 350 and 355register a balanced threshold signal indicating alignment to the eye 125and a distance that is within a target range to the eye 125. In someembodiments, the target range to the eye (illustrated as L in FIG. 18)is about 10 mm to about 30 mm. In some embodiments, L is between about15 mm and 20 mm.

Reflections from the eye 125 can be detected in the 15-25 mm range butpredicted spatial orientation and alignment is often inaccurate whenbased on information from only one photo proximity pair (i.e., LED andphotodiode combination). As such, the positioning of the two sensors 350and 355 at an equal distance from the nozzle 37 results in off-axisreflected signals that can be compared. Typically, users canhorizontally orient a device very accurately and can align thehorizontal position accurately but suffer from poor judgement in termsof vertical angular and vertical spatial targeting. Moreover, the eye125 typically has only 8-9 mm of clearance between the eyelids, but 18mm of clearance over the horizontal sclera of the eye 125. As such, theclearance over the horizontal sclera is much greater than the clearance140 between the eyelids. In addition, because of the natural curvatureof the eye (typically a radius of 11.5-12.5 mm), it is difficult todirect most of the light normal to the eye 125 to optimize reflectedsignal intensity without mounting SMD photo proximity sensors on anangled substrate, which would result in increased cost. As such, theblink detector 295 may also include micro prisms 360 and 365 that directthe light closer to normal to the scleral and corneal surface of the eye125, and increase the reflection signal when the eye 125 is in theoptimal distance and position normal to their path. Thus, the sensors350 and 355 and the micro prisms 360 and 365 can be used as anelectronic means to detect optimal alignment of the nozzle 37 to theeyeball as well as blink detection.

When the nozzle 37 includes a plurality of openings, for example 8-10openings roughly 300 μm in diameter and adequately spaced apart to allowfor nozzle cone angle and low hydraulic losses, the dimension 120 a ofthe array 120 is approximately 14 mm. As such and in some embodiments,the sensors 350 and 355 and respective micro prisms 360 and 365 areseparated by about 16 mm. However, the spacing of the sensors 350 and355 may be based on the size of the cartridge 15 and nozzle 37 and maybe slightly closer together for a slit nozzle. In some embodiments, thearrangement allows an optimal micro prism angle α (illustrated in FIG.18 ) for a glass (n=1.5) that maximizes the scattering of the reflectedlight back into the photodiode detectors of the sensors 350 and 355. Insome embodiments, the micro prisms 360 and 365 are omitted.

In the vertical direction, as long as the divergence of the rays of theLED are in the range of +/−20 degrees, which is very typical, anadequate signal will be obtained, as illustrated in FIG. 19 .

In some embodiments, the sensors 350 and 355 are 940 nm opticalproximity sensors with detector coatings to reject sunlight outside of a+/−10 nm range. In some embodiments, natural sunlight overwhelms theamplifier signal when the impinging infrared background radiation in thewavelength range is less than 930 nm and greater than 950 nm. At 940 nm,natural sunlight has atmospheric absorption and a deep transmission dipsuch that very little radiation is present centered at this wavelengthat the surface of the earth. As such, in some embodiments the sensors350 and 355 are configured to have an LED that emits radiation at 940 nmand only detect wavelengths of 940 nm+/−10 nm or even more narrowly 940nm+/−5 nm. This prevents DC detector saturation from natural sunlight.Other smaller background sources of lighting can easily be compensatedfor by pulsing the proximity sensors at an AC frequency and filteringout the remaining DC background.

In some embodiments, a photocurrent signal can be dropped across adetection resistor in the kΩ range and the voltage thus obtained can bebuffered and low pass filter with a lower bounds threshold signal inboth the left and right proximity sensors 350 and 355 to ensure theophthalmic delivery device is well situated near the eye 125. Inaddition, a threshold matching signal error value between thephotodiodes can be chosen to ensure the horizontal positioning orrotational angle of the device is level with the eye 125. Blinkdetection can be achieved by sampling and picking off a sharp transientsignal that is typically higher in amplitude due to increased backscattering into the detector.

In some embodiments, alignment of the nozzle 37 with the eye 125involves a combination of dimensional (i.e., along x, y, and z axes)alignment and angular position of the nozzle relative to the eye 125. Asthe surface of the eye 125 is curved, there are multiple combinations ofdimensional alignment and angular position that result in the nozzle, ora longitudinal axis of the one or more openings, being aligned with theeye 125. Generally, there are three angles of rotation in pointing thenozzle 37 towards the eye 125. The first angle of rotation is in the“right” and “left” directions between nose and ear. Because the exposedpart of the eye is much wider in this direction than it is tall (i.e.,between eyelids), the rotational axis of the applicator sweeping alongthe left right direction towards the eye is not critical. The secondangle of rotation is in the “top” and “bottom” directions or verticaldirection between eyelids. The applicator being rotated along this angleof rotation is much more critical considering there is less exposure ofthe eye in this direction, and the proximity sensors 350 and 355 looksfor a rotation that gives the best signal in between the two eyelidsalong this direction. The third angle of rotation is in a “clockwise” or“counterclockwise” direction of the nozzle relative to the eye. Again,the proximity sensors 350 and 355 look for a rotation that gives thebest signal in this angle of rotation as well. Alignment of the nozzle37 is indicated by the two proximity sensors 350 and 355 havingsubstantially equal signals; otherwise one signal will likely be apartial reflection off part of an eyelid and one will not. Therefore,for the photodetector signals to indicate alignment, they must be adesignated narrow amplitude range indicative of hitting the eyeballsclera as well as substantially equal in amplitude. In some embodiments,alignment of the nozzle 37 involves a longitudinal axis of the one ofmore openings being aligned with a surface of the eye such that anejection of a fluid from the opening is aimed toward the surface of theeye 125.

In an example embodiment, the nozzle 37 is aligned directly with a lightsource, such as an LED (e.g., aligned without parallax), which permitsthe user to see the light from the light source only when the nozzle 37is correctly aligned toward the eye 125 within a range of positions andorientations. The applicator 15 may not require gravity to function, andthus may function regardless of orientation. The applicator 15 may alsoinclude passive features intended to rest against a user's forehead orcheekbone to aid in proper alignment of the device. In one aspect, andwhen portions of the head 35 are transparent, a single or multicolor LEDcan be placed directly behind the nozzle 37 of the applicator 15 toallow for direct aiming of the nozzle 37 into the eye. With appropriateaperturing of the light rays, these rays can be confined to a smallangular range that can directly pass through the one or more openings(e.g., 85, 160, 170, or 180) such that the light rays from the lightsource are only visible when correctly aligned with the eye 125. A userwill then only see the colored LED light with high visual acuity overtheir eye's fovea color receptive region within a narrow aiming rangesuch as +/−10 degrees, which assists the user in correctly aiming thedevice towards the eye 125, assuming the LED brightness is appropriatelychosen.

If the applicator 15 distance is too far (e.g., more than 20 mm from theeye), the light source may be controlled to change in color or inillumination pattern (e.g., blinking, strobing, pulsing, solid) forexample. Further, if the applicator 15 is close enough to be in range itcan be changed from a first color to a second color. For example, blueand orange may be a common colorblind-friendly palette. However, anysuitable color and color combination can be used. An RGB LED can beused, which is capable of a wide color gamut by adjusting relativecurrents to each LED. The intensity of the LED can also optionally beflickered or strobed to be used in a similar manner to a blink-defeatingsignal in a flash camera. Thus, through color changing and time domainchanging signals, range, alignment, and aiming can be communicated tothe user while they are holding the device, greatly improving the easeof use of the device.

In some embodiments, the blink detector 295 includes or is incommunication with the controller 290 that instructs the trigger 305 toactivate or to dispense a dose. In some embodiments, the controller 290determines whether the applicator 15 is being manually armed (e.g., isthe user pressing the mechanical activation button 320) by checking an“ON” signal. In some embodiment, the controller 290 also determineswhether the low pass filtered optical reflective sensor targetingsignals for the sensors 350 and 355 are above threshold voltage for boththeir average values and below threshold for their difference values. Insome embodiments, the controller 290 has at least 2 separate 8 bit ADCchannels and the low pass filter is easiest to implement in softwareafter the raw data has been captured by the analog to digitalconverters. In some embodiment, the controller 290 also determineswhether the unfiltered higher bandwidth blink signals should trigger anON signal on a quick rising or falling edge transition of the proximitysensors signifying that a blink is beginning or ending. The details ofwhether the rising or falling edge of the proximity sensor signalsignifies a blink opening or closing depend upon the alignment of thecentral ray of the proximity sensor LEDs. FIG. 20 illustrates a timelinedesignated by the numeral 366 during which the controller 290 determinesthat a blink has occurred and causes the trigger 305 to dispense a dose.Generally, the light from the blink detector LEDs is pulsed at afrequency between 100 Hz and 10 kHz which is much faster than a blinktransient at the 10 Hz level. The DC component of the correspondingoptical sensors is filtered out. The remaining AC component is amplifiedand filtered into a smooth function over time. Generally, there is abaseline transimpedance amplified noisy signal from the proximity sensorwhen it is far away from the eye, which is indicated by a ripple signaldue to background lighting and noise. Once the applicator 15 is broughtwithin aiming distance to the eye 125, a higher value base signaldetected. When the user blinks, the higher value base signal spikes.FIG. 20 illustrates a line 366 a that represents an expected ripplesignal that is associated with the sensors not being aligned with theeye; a line 366 b that represents an expected higher value base signalthat is associated with the sensors being aligned with the eye; and aline 366 c represents an actual signal over time as the sensors arealigned with the eye (e.g., when the line 366 c is close to the line 366b) and then a transient spike 366 d of the line 366 c that is associatedwith the user closing and then opening the eyelids. As illustrated, theline 366 c returns to the baseline 366 b after the user re-opens his orher eyelids. Generally, when the higher value base signal is balancedbetween both proximity sensors, then as the user blinks two blinksignals will be recorded as the transient spike upon closing and openingthe eyelids. In general, when the eyelids are closed the signal isstronger as long as the primary central axis LED ray hits the eyeballslightly off-axis. The details of how these signals are shaped and theirdetailed amplitude and time domain characteristics vary slightly fromone person to the next based on eyelashes, skin color, and blinkduration, and machine learning can be used to pinpoint thecharacteristic transient signals of each individual user and store thisdata in memory to help perfect the blink detection algorithms.

In some embodiments, the trigger 305 is or includes an electromechanicalsolenoid that strikes the elastomeric wall 55. In other embodiments andas illustrated in FIG. 21 , the trigger 305 is or includes anelectromechanical solenoid 367 that is coupled to an arm or latchtrigger 368 that strikes the wall 55. Generally, the trigger 305 isactivated by an electrical signal and causes a hard tip object (e.g.,portion of solenoid or latch trigger 368) to strike the wall 55 andcreates an instantaneous impulse of momentum that imparts a pressureshock wave that builds up pressure suddenly in the holding chamber 62and imparts positive displacement of the fluid through the nozzle 37.The holding chamber 62 accommodates fluid prior to ejection. The impactcan come from any type of mechanical mechanism that builds up mechanicalenergy including, such as for example a leaf spring with a pullbackmechanism, a torsional spring with windup mechanism, or a hammer with acocking and trigger mechanical mechanism. In some embodiments, thetrigger 305 includes a direct solenoid that is of the bi-stable typeusing springs and/or magnets that can have a holding force large enoughto maintain the wall 55 in a displaced state in which the wall 55 coversthe opening(s) of the nozzle 37. Generally, the wall 55 can be displacedby any mechanical mechanism with sufficient impact force. Building uptoo low a momentum during the strike of the wall 55 can result inviscous drool out of the nozzle 37 as the wall 55 stops too slowly uponcovering or contacting the interior surface of the nozzle 37. In someembodiments, the velocity of the fluid out of the nozzle 37 is between1.5 m/s and 3 m/s. However, in some embodiments, the velocity at whichthe fluid is ejected is between about 1.5 m/s to about 2 m/s. Moreover,with a volume of liquid delivered of 10-15 μl, the stream must be fastenough to defeat the blink reflex at approximately less than 100 ms.However, by triggering off the opening of an eye blink, extra time isafforded as it takes longer to turn a blink around from an opening stateto re-closing of the eyelids. In general, the total time to deliverliquid to the eye is well under 100 ms, as the blink detection circuittakes under 40 ms, the solenoid actuation takes under 10 ms, themovement of the wall takes under 5 ms, and the ejection of fluid takesunder 20 ms. Another issue with too low a strike impact can result intoo low a velocity below 1.5 m/s resulting in loss of aiming from agravitational parabolic trajectory. Too high a velocity, however, canresult in a noticeable unpleasant impact on the eye 125. Because of thehigh mass of the striker, it is not necessary that the strike velocitybe the same as the microstream ejected from the nozzles. In someembodiments, to achieve a “sheet” microstream having a velocity ofbetween 1.5-3 m/s, the average velocity of the portion of the trigger305 striking the wall 55 is at least 0.5 m/s and up to 3 m/s at themoment of impact and a momentum mass coming from a hammer or a directsolenoid armature if made from metal is between 2 grams and 3 grams. Inorder for the wall 55 to shut off the nozzle 37 and maintain itspositive displacement after the strike, there is an additional holdingforce typically between 0.5 N-2N required for maintaining the wall 55 inthe full displaced state. However, the exact force depends upon theexact elastic mechanical properties and geometry of the elastomer wall.

In some embodiments, the nozzle cap 50 is opened prior to the ejectionof the fluid by a mechanical linkage to the activation button 320 whenthe cartridge 20 is inserted in the applicator 15. Because the cap 50 isan integral part of the head 35 in some embodiments, it does not need tomaintain mechanical integrity for years but only as long as thecartridge 20 itself is used, typically 1-2 months and thus the cap 50 isdisposed of with the cartridge 20. In a typical eye dropper devicebottle, a user manually releases squeeze pressure and non-sterile airre-enters through the same nozzle. With this device 10, the nozzle 37can be recapped via the cap 50 before the wall 55 is released and theholding chamber 62 draws in new fluid. This simultaneously allows forsterile filtered air to be taken in through a separate sterile airintake filter (e.g., air entry port 45) to achieve equal pressurization.

In some embodiments and as illustrated in FIGS. 22 and 23 , there is anadditional sterilizer 300 that consists of one or two ultraviolet (“UV”)light emitting diodes (“LEDs”) that are positioned relative to thenozzle 37 such that the nozzle 37 is exposed to an LED light cone 301through either the tip of the nozzle head or the cap 50. In addition,and in some embodiments, because constant power to the UV LED uses asubstantial amount of battery energy, the UV LED can be turned on justafter an application to the eye and after the dust cover 325 isre-closed for protection. Due to the close proximity of the UV LED tothe nozzle 37, only a few seconds of exposure is necessary for sterilityusing the appropriate wavelength. At the appropriate UVC wavelengthrange of 285 nm for example, the UV LED is known to kill viruses,bacteria, and even molds very effectively with over 10{circumflex over( )}3 reductions with only millijoules of energy over a concentratedclose proximity area. The use of the UV LED is an extra precaution thatmeans any residue remaining at the tip is re-sterilized. In theembodiments in which the cap 50 extends between the nozzle 37 and thesterilizer 300, for example as illustrated in FIG. 23 , the cap 50and/or material forming the moisture chamber 515 is at least partiallytransparent to the UV wavelength and is made from UV stabilizedmaterials.

In some embodiments, a UV shield 370 is applied over a portion of thenozzle 37 or other portion of the head 35. For example, the UV shield370 may include a thin layer of sputtered SiO2 or metal to prevent aportion of the nozzle 37 from exposure to the UV light. In someembodiments, the UV shield 370 prevents the potential for degradation ofa drug component of the viscous fluid in the main holding chamber 62 andonly affects a small concentrated area around the nozzle.

As illustrated in FIG. 22 , an example sterilizer 300 that includes aSMD UV LED is coupled to the applicator 15 and situated near the nozzle37. An example of a SMD UV LED includes for example the L944-UV265-4 265nm domed UVC LED from American Opto Plus LED. In addition to UV-C LEDskilling bacteria, UV-C LEDs also kill mold spores. While described as asterilizer 300, the sterilizer 300 is not required to kill all of thebacteria, viruses, and fungi. Instead, the sterilizer 300 may kill orreduce a significant portion of the bacteria, viruses, and fungi byseveral orders of magnitude. In some cases, this may result in oculardrug formulations which can be completely preservative free, which ishighly desirable. In other cases, the use of preservatives may bedramatically reduced. It should be noted that under operations, thenozzle cover 50 is not touched or removed by the user from the cartridgein any way but is permanently tethered to it at some point, and is heldback further from the eyelashes than a normal eye dropper. Generally,the dust cover 325 of the applicator 15 also keeps the nozzle cover orcap 50 clean and prevents UV from leaking outside the applicator whenthe sterilizer 300 is turned on. The only chance for biologicalcontamination is an airborne event during liquid dispensing. However,the diffusion time and diffusion rates for even the fastestself-propelled bacteria is slow enough so as to be killed by the UVlight near the nozzle 37 before any growth can take place. Additionally,the nozzle 37 is covered internally by the elastomeric wall 55 afterdispensing events, which acts as a valve trapping any such biologicalcontamination. In some embodiments, the wall 55 can remain against thenozzle 37 until after a brief UV exposure has taken place.

In some embodiments, the power source 285 is a rechargeable battery,such as a small coin cell of LiPo battery.

In some embodiments, the transmitter 280 of the applicator 15 is incommunication with the transmitter 265 of the cradle 255. Communicationbetween the transmitters 280 and 265 and/or between the transmitters 280and 265 and the remote device 250 allow for tracking the use of thedevice 10. In some embodiments, communication and connectivity betweenthe cradle 255, the applicator 15, and/or the remote device 250 allowsfor time and date tracking of medications, syncing between differentdevices that are similar or identical to the device 10, auto-re-orderingof medications, providing battery recharge reminders, providingreminders to the user to take medication, enables doctor/patientsharing, improving telemedicine options, and/or tracks treatmentcompliance. Communication and connectivity between the cradle 255, theapplicator 15, and/or the remote device 250 allows for the applicator 15to be trained based on historical data. Some examples of training theapplicator 15 include updating algorithms and/or calculations using dataregarding scleral baseline proximity reflection, skin reflection,movement off axis and centering signals, and blink temporal dynamics.

In an example embodiment, as illustrated in FIG. 24 with continuingreference to FIGS. 1-23 , a method 400 of operating the device 10includes loading the cartridge 20 in the applicator 15 at step 405;manually enabling the applicator 15 and opening the dust cover 325 atstep 410; detecting a blink and dispensing a dose at step 415; recordingdata associated with the dispensed dose at step 420; sterilizing thenozzle 37 at step 425; and communicating the recorded data via thetransmitters 265 and 280 at step 430.

At step 405 and in one embodiment, the cartridge 20 is loaded in theapplicator 15. In some embodiments, the cartridge 20 is disposable.Generally, when the cartridge 20 is accommodated in the applicator 15but the applicator 15 is not loaded, the head 35 is in a firstconfiguration as illustrated in FIG. 25A. As illustrated, the cap 50 ispositioned against the nozzle 37 and the wall 55 is not depressed. Fluidis accommodated in the holding chamber 62.

At the step 410 and in one embodiment, the applicator 15 is activatedwith mechanically or electrically loaded energy preparing for a striketo wall 55. One example of the applicator 15 being manually enabled iswhen the user depresses the activation and the mechanical activationbutton 320. The head 35 transitions from the first configuration to asecond configuration in which the cap 50 is spaced from the nozzle 37such that the fluid exiting the nozzle 37 will clear the cap 50, asillustrated in FIG. 25B. In some embodiments, the applicator 15 isenabled when the user depresses mechanical activation button 320 but isnot fired until the blink detector 295 determines that the applicator 15is correctly positioned relative to the eye 125 of the user and inresponse to a detected blink.

At the step 415 and in one embodiment, a blink is detected and a dose isdispensed. As detailed above and illustrated in FIG. 19 , the blinkdetector 295 determines that the nozzle 37 is aligned with the eye 125and detects a blink. Upon detecting a blink, the controller 290 sends asignal to the trigger 305 to dispense the dose. The head 35 alsotransitions from the second configuration to the third configuration inwhich the wall 55 is depressed to force the fluid from the holdingchamber 62 via the nozzle 37, as illustrated in FIG. 25C. The externalimpact to the wall 55 should be sudden and much faster than the eyeblink reflex time of approximately 100 ms. In one embodiment, the impactduration is on the order of 10 ms or faster. Generally, the wall 55 ismade from a soft enough elastomeric material that the wall 55 highlydampens out any rebounds from this strike impact and also soft enoughthat the inertia resisting the impact of this strike can be largelyattributed near the end of motion to the squeeze-film damping of thefluid itself. In some embodiments, the wall 55 is hit with aninstantaneous impulse of momentum already in motion which imparts apressure shock wave that builds up pressure suddenly. After dispensing,the head 35 also transitions from the third configuration to the fourthconfiguration in which first the cap 50 extends over the nozzle 37 andthen the wall 55 is released from its depressed state and the, whichprevents air from being drawn in through the nozzle 37 and instead drawsfluid from the chamber 40 into the holding chamber 62, as illustrated inFIG. 25D.

At the step 420 and in some embodiments, the controller 290 records dataassociated with the dispensed dose. In some embodiments, the controllerrecords data detected by the blink detector 295 and data detected orgenerated by the trigger 305. As such, the controller 290 detects thetiming of each dose being dispensed. Moreover, the controller 290 candetect and record a blink speed of the user.

At the step 425 and in some embodiments, after the dust cover 325 isreclosed, the sterilizer 300 sterilizes the nozzle 37 at step 425. Insome embodiments and in response to a detected dose being dispensed bythe controller 290, the controller 290 activates the sterilizer 300 fora predetermined period of time to sterilize a portion of the nozzle 37and/or fluid passing via the nozzle 37.

At the step 430 and in some embodiments, the recorded data iscommunicated via the transmitters 265 and 280. In some embodiments, therecorded data is transmitted to the transmitter 265 and/or the remotedevice 250. In some embodiments, data is transmitted from thetransmitter 265 to the transmitter 280. In some embodiments, therecorded data is stored in the controller 275. However, the recordeddata is also stored or received by the remote device 250 via the network260. The controller 290 may upload and update the recorded data, whichmay span months to years, to a cloud-based database via the controller275. This recorded data can be used to update, customize, and generatepredictive models to refine dry eye management over the course of hoursto days. The models may include a variety of factors includinghistorical, current, and expected or predicted external factors, whichare used to generate predictive models.

FIG. 26 illustrates another embodiment of the cartridge 20 designatedwith the reference numeral 500. In some embodiments, and instead of arectangular shaped body, the housing 30 is cylindrical shaped. Moreover,the cartridge 500 includes a head 505, that may optionally include acylindrical protective head cover the user removes before loading thecartridge 500 into the applicator that is another embodiment of the head35. As illustrated in FIGS. 26 and 27 , the head 505 is similar to thehead 35 in that it includes the wall 55 and the nozzle 37 that form theholding chamber 62. In this embodiment, the air vent 45 is positioned ona top side of the head 505 (e.g., a side that includes the wall 55)instead of a bottom side (e.g., a side that includes the nozzle 37). Insome embodiments, the cap 50 of the head 505 is not integrally formedwith the wall 55 and is instead coupled to a spring 510 or otherenergy-storage device that forms a portion of the head 505. As discussedpreviously, the cap 50 stays in a closed position unless fluid is aboutto be or is being ejected from the nozzle 37 at which time the cap 50transitions into an open position. In some embodiments and asillustrated in FIG. 26-28 , the cap 50 is spaced from the nozzle 37 whenin the closed position to form a moisture chamber 515 between the nozzle37 and the cap 50. In some embodiments, spacing of the cap 50 from thenozzle 37 when in the closed position reduces the likelihood ofcontaminating the nozzle 37 with the cap 50 as the nozzle is neverdirectly touched. FIG. 28 is a close up cutaway is one that contains twoslots like the oblong openings also depicted in FIG. 27 .

In some embodiments and as illustrated in FIG. 29 , the nozzle 37 formsa single opening or more than one opening that extends along a direction520 and the internal surface 105 forms a concave-like or curved surfaceand the external surface 115 forms a convex-like or curved surface. Thesurfaces 105 and 115 being curved encourages the fluid exiting thenozzle 37 to form a more fan-like shape after exiting. That is, fluidexiting opposing edges of the nozzle 37 exit at an angle B that is notperpendicular to the direction 520. In some embodiments, the surfaces105 and 115 being curved encourages the resulting drop footprint to bemore highly elliptical or an eccentric stadium shape rather than morerounded in profile or oval shaped for larger travel distances to theeye.

In some embodiments, the wall 55 has an interior surface 55 a that formsa portion of the holding chamber 62 and that contacts the interiorsurface 105 during the ejection of the fluid. In this embodiment, when aforce is applied on the wall 55, the wall 55 deforms towards the nozzle37 thereby reducing the volume of the holding chamber 62 and forcing thefluid from the nozzle 37. Moreover, the wall 55 deforms until theinterior surface 55 a contacts the nozzle 37 inner face, or interiorsurface 105, thereby sealing or otherwise temporarily blocking theopenings. As such, movement of the wall 55 toward the nozzle 37 not onlydisperses the fluid but closes the openings of the nozzle 37 to end theejection of the fluid. As such and in some embodiments, the wall 55forms a valve that closes the nozzle 37. Movement of the wall 55 to itsnatural state (after being struck) fills the holding chamber 62 withfluid from the chamber 40 to prepare for another ejection of fluid. Insome embodiments and as illustrated in FIGS. 26-29 , there are two slitopenings 525 and 530 that extend in parallel along the direction 520 toform an oblong shape.

In some embodiments and as illustrated in FIG. 30 , a single nozzleopening is formed 535 that generally extends the direction 520 withrepeating “S” shapes to form an oblong shape. This shape has largerundulations as discussed in FIG. 11 that allow for a large volume offluid to be dispensed under the same strike energy with a singlemicrostream tail in a confined nozzle face area.

In some embodiments and as illustrated in FIGS. 31-32 , the sterilizer300 includes a first and second head 540 and 545 that emit UV light fromopposing sides of the head 505 towards the nozzle 37 or the nozzlemoisture chamber 515. In this embodiment, the slots 525 and 530 extendbetween the first and second heads 540 and 545 and the light is emittedin a generally parallel direction to the direction 520.

In some embodiments, the device 10 includes a simple cartridge 20 thatis placed in a smart applicator 15 that has a cradle 255 that allows forthe continuous or intermittent sterilization of the nozzle 37.

In some embodiments, the nozzle 37 is a polypropylene (PP) orpolyethylene (PE) plastic molded nozzle. In some embodiments, the head35 includes polypropylene as it has favorable material properties forbeing directly welded to the elastomer material of the wall 55, such aswith a precision high speed laser welding process. In some embodiments,the cap 50 is an over molded or welded elastomer flap. In someembodiments, the wall 55 is a heat bonded, ultrasonically bonded orlaser welded to another portion of the head 35. Generally, the wall 55facilitates easy squeezing (i.e. low displacement forces) of fluid outof the holding chamber 62 and through the nozzle 37. If the wall 55 isconnected to the cap 50, it also allows easy self-contained capping ofthe nozzle 37 which conforms to microscopic surface roughness after adispensing event. The wall 55 may be formed from any material thatheat-welds with strength to PE or PP. In some embodiments, the wall 55is or includes a compatible medical grade version of thermoplasticelastomers (TPEs) known as thermoplastic vulcanizates (“TPVs”) with a PPcross linked polymer backbone incorporating a vulcanized rubberelastomer. In some embodiments, the TPEs may include for example medicalgrades of Santoprene® from ExxonMobil Chemical, Medalist® from TeknorApex, or ProFlex™ SEBS from Foster Corporation, which have chemical andmelt compatibilities with both PE and especially PP and performancecharacteristics such as a low amount of compression set. In someembodiments, durometer values for the material forming the wall 55 arein the range of 40-60 Shore A, making them much less rigid and moredeformable than PE or PP.

The device 10 is not limited to delivery of fluids to the eye, but couldalso deliver fluids to the nose via a nasal spray, as higher viscosityin nasal sprays is advantageous for improving the residence time of thedrug on the nasal mucosal lining.

In some embodiments, the device 10 includes a flow mechanism or generalconfiguration to prevent uptake of unsterile air such that it maintainsinternal pressure and sterility over a prescribed amount of time.

In an example embodiment, the network 260 includes the Internet, one ormore local area networks, one or more wide area networks, one or morecellular networks, one or more wireless networks, one or more voicenetworks, one or more data networks, one or more communication systems,and/or any combination thereof.

In some embodiments, a viscous fluid is a fluid having a high viscosityof 50 cps to 200 cps. While this high viscosity has been a focus ofdiscussion, it should be noted that lower viscosities in the range of0.5-50 cps can be used if the nozzle slit width and strike force areoptimized.

In an example embodiment, as illustrated in FIG. 34 with continuingreference to FIGS. 1-23, 24A, 24B, 24C, and 24D, an illustrative node1000 for implementing one or more of the example embodiments describedabove and/or illustrated in FIGS. 1-9A, 9B, 23, 24A, 24B, 24C, 24D, and25-33 is depicted. The node 1000 includes a microprocessor 1000 a, aninput device 1000 b, a storage device 1000 c, a video controller 1000 d,a system memory 1000 e, a display 1000 f, and a communication device1000 g all interconnected by one or more buses 1000 h. In severalexample embodiments, the storage device 1000 c may include a floppydrive, hard drive, CD-ROM, optical drive, any other form of storagedevice and/or any combination thereof. In several example embodiments,the storage device 1000 c may include, and/or be capable of receiving, afloppy disk, CD-ROM, DVD-ROM, or any other form of computer-readablemedium that may contain executable instructions. In several exampleembodiments, the communication device 1000 g may include a modem,network card, or any other device to enable the node to communicate withother nodes. In several example embodiments, any node represents aplurality of interconnected (whether by intranet or Internet) computersystems, including without limitation, personal computers, mainframes,PDAs, smartphones, and cell phones.

In several example embodiments, one or more of the components of thesystems described above and/or illustrated in FIGS. 1-9A, 9B, 23, 24A,24B, 24C, 24D, and 25-33 include at least the node 1000 and/orcomponents thereof, and/or one or more nodes that are substantiallysimilar to the node 1000 and/or components thereof. In several exampleembodiments, one or more of the above-described components of the node1000, the device 10, and/or the example embodiments described aboveand/or illustrated in FIGS. 1-9A, 9B, 23, 24A, 24B, 24C, 24D, and 25-33include respective pluralities of same components.

In several example embodiments, one or more of the applications,systems, and application programs described above and/or illustrated inFIGS. 1-9A, 9B, 23, 24A, 24B, 24C, 24D, and 25-33 include a computerprogram that includes a plurality of instructions, data, and/or anycombination thereof; an application written in, for example, Arena,HyperText Markup Language (HTML), Cascading Style Sheets (CSS),JavaScript, Extensible Markup Language (XML), asynchronous JavaScriptand XML (Ajax), and/or any combination thereof; a web-based applicationwritten in, for example, Java or Adobe Flex, which in several exampleembodiments pulls real-time information from one or more servers,automatically refreshing with latest information at a predetermined timeincrement; or any combination thereof.

In several example embodiments, a computer system typically includes atleast hardware capable of executing machine readable instructions, aswell as the software for executing acts (typically machine-readableinstructions) that produce a desired result. In several exampleembodiments, a computer system may include hybrids of hardware andsoftware, as well as computer subsystems.

In several example embodiments, hardware generally includes at leastprocessor-capable platforms, such as client-machines (also known aspersonal computers or servers), and hand-held processing devices (suchas smartphones, tablet computers, personal digital assistants (PDAs), orpersonal computing devices (PCDs), for example). In several exampleembodiments, hardware may include any physical device that is capable ofstoring machine-readable instructions, such as memory or other datastorage devices. In several example embodiments, other forms of hardwareinclude hardware subsystems, including transfer devices such as modems,modem cards, ports, and port cards, for example.

In several example embodiments, software includes any machine codestored in any memory medium, such as RAM or ROM, and machine code storedon other devices (such as floppy disks, flash memory, or a CD ROM, forexample). In several example embodiments, software may include source orobject code. In several example embodiments, software encompasses anyset of instructions capable of being executed on a node such as, forexample, on a client machine or server.

In several example embodiments, combinations of software and hardwarecould also be used for providing enhanced functionality and performancefor certain embodiments of the present disclosure. In an exampleembodiment, software functions may be directly manufactured into asilicon chip. Accordingly, it should be understood that combinations ofhardware and software are also included within the definition of acomputer system and are thus envisioned by the present disclosure aspossible equivalent structures and equivalent methods.

In several example embodiments, computer readable mediums include, forexample, passive data storage, such as a random-access memory (RAM) aswell as semi-permanent data storage such as a compact disk read onlymemory (CD-ROM). One or more example embodiments of the presentdisclosure may be embodied in the RAM of a computer to transform astandard computer into a new specific computing machine. In severalexample embodiments, data structures are defined organizations of datathat may enable an embodiment of the present disclosure. In an exampleembodiment, a data structure may provide an organization of data, or anorganization of executable code.

In several example embodiments, any networks and/or one or more portionsthereof may be designed to work on any specific architecture. In anexample embodiment, one or more portions of any networks may be executedon a single computer, local area networks, client-server networks, widearea networks, internets, hand-held and other portable and wirelessdevices, and networks.

In several example embodiments, a database may be any standard orproprietary database software. In several example embodiments, thedatabase may have fields, records, data, and other database elementsthat may be associated through database specific software. In severalexample embodiments, data may be mapped. In several example embodiments,mapping is the process of associating one data entry with another dataentry. In an example embodiment, the data contained in the location of acharacter file can be mapped to a field in a second table. In severalexample embodiments, the physical location of the database is notlimiting, and the database may be distributed. In an example embodiment,the database may exist remotely from the server, and run on a separateplatform. In an example embodiment, the database may be accessibleacross the Internet. In several example embodiments, more than onedatabase may be implemented.

In several example embodiments, a plurality of instructions stored on acomputer readable medium may be executed by one or more processors tocause the one or more processors to carry out or implement in whole orin part the above-described operation of each of the above-describedexample embodiments of the system, the method, and/or any combinationthereof. In several example embodiments, such a processor may includeone or more of the microprocessor 1000 a, any processor(s) that are partof the components of the system, and/or any combination thereof, andsuch a computer readable medium may be distributed among one or morecomponents of the system. In several example embodiments, such aprocessor may execute the plurality of instructions in connection with avirtual computer system. In several example embodiments, such aplurality of instructions may communicate directly with the one or moreprocessors, and/or may interact with one or more operating systems,middleware, firmware, other applications, and/or any combinationthereof, to cause the one or more processors to execute theinstructions.

The present disclosure introduces a fluid dispensing device thatincludes: a cartridge including a housing and a head coupled to thehousing; wherein the housing forms a first chamber configured toaccommodate a fluid; and wherein the head includes: a nozzle; and anelastomeric wall that is spaced from the nozzle to form a holdingchamber; wherein the holding chamber is in fluid communication with thefirst chamber and configured to accommodate a portion of the fluid priorto ejection; wherein the nozzle forms one or more openings to eject theportion of the fluid from the holding chamber; and wherein the one ormore openings form an oblong shape such that a length of the oblongshape is greater than a width of the oblong shape. In some embodiments,the device also includes an applicator sized to accommodate thecartridge; wherein the applicator includes an actuator movable between aloaded position and a striking position; wherein, when in the loadedposition, the actuator is spaced from the elastomeric wall; and wherein,when in the striking position, the actuator has compressed theelastomeric wall toward the nozzle to eject the portion of the fluidfrom the holding chamber via the one or more openings. In someembodiments, the applicator further includes: a controller that controlsthe position of the actuator; and a blink detector that is operablycoupled to the controller, wherein the blink detector includes aplurality of sensors; wherein each of the sensors includes alight-emitting diode to emit light onto a surface of an eye of a userand photodiode to detect reflection of the light emitted onto thesurface of the eye; and wherein, based on the light detected by thephotodiode of each sensor, the controller determines whether the userhas blinked the eye. In some embodiments, the wavelength of lightdetected by the photodiode is from about 930 nm to about 950 nm. In someembodiments, the one or more openings include two parallel slots thattogether form the oblong shape. In some embodiments, the one or moreopenings include a plurality of openings arranged linearly to form theoblong shape. In some embodiments, a portion of the nozzle forming theone or more openings forms a concave internal surface and a convexexternal surface. In some embodiments, the elastomeric wall is movablebetween a first position relative to the one or more openings and asecond position relative to the one or more openings; wherein, when inthe first position, the elastomeric wall is spaced from the one or moreopenings; wherein, when in the second position, the elastomeric wallblocks the one or more openings; wherein moving the elastomeric wallfrom the first position to the second position ejects the fluid from theholding chamber; wherein, when in the second position, the elastomericwall fluidically isolates the one or more openings from the firstchamber; and wherein, when moving the elastomeric wall from the secondposition to the first position fluid is drawn from the first chamberinto the holding chamber. In some embodiments, the applicator furtherincludes an ultraviolet (“UV”) light emitting diode positioned such thatthe UV light shines on at least a portion of the nozzle. In someembodiments, the UV light is between 265 nm and 285 nm; wherein theelastomeric wall includes a thermoelastic polymer including a thermoplastic vulcinate; and wherein the head forms an air entry port in fluidcommunication with the first chamber and further includes a sterile airfilter that is welded to the head such that the sterile air filterfilters the air passing through the air entry port.

The present disclosure also introduces a method of dispensing a viscousfluid from a fluid dispenser that includes a pair of light-emittingdiodes and corresponding pair of photodiodes, a nozzle having one ormore openings that form an oblong shape, a flexible membrane, a holdingchamber positioned between the nozzle and the flexible membrane, acontroller, and an actuator that is operably coupled to the controller,the method including: emitting light onto a surface of an eye using thepair of light-emitting diodes; detecting an amount of light reflectingfrom the surface of the eye using the pair of photodiodes; andactuating, using the controller and based on the amount of detectedlight, the actuator to depress the flexible membrane into the holdingchamber thereby causing the viscous fluid to be ejected from the holdingchamber through the one or more openings of the nozzle. In someembodiments, the method also includes shining ultraviolet (“UV”) lightfrom an UV light-emitting diode (“LED”) onto a portion of the nozzle tosterilize the portion of the nozzle. In some embodiments, shining the UVlight occurs for a predetermined period of time in response to thecontroller actuating the actuator. In some embodiments with opticalproximity sensors for blink detection, the wavelength of light emittedby their LEDs and detected by the pair of photodiodes is from about 935nm to about 945 nm. In some embodiments, the actuator includes anelectromechanical solenoid. In some embodiments, the method alsoincludes generating data regarding the actuation of the actuator; andcommunicating the data to a remote controller. In some embodiments, theoblong shape formed by the one or more openings has a length that isgreater than a width; wherein the method further includes the controllerdetermining that the length of the oblong shape is positioned generallyparallel to the eyelids of the user based on the amount of lightreflecting from the surface of the eye; and wherein ejecting the viscousfluid from the fluid dispenser is in response to the controllerdetermining that the length of the oblong shape formed by the one ormore openings is positioned generally parallel to the eyelids.

The present disclosure also introduces a method of dispensing one ormore streams of viscous fluid on an eye of a user, the method including:accommodating the viscous fluid in a holding chamber of a cartridge,wherein the cartridge includes a nozzle having one or more openings thatform an oblong shape, a flexible membrane, and wherein the holdingchamber is positioned between the nozzle and the flexible membrane; andactuating a solenoid that depresses the flexible membrane to eject theone or more streams of the viscous fluid from the one or more openingsat a velocity targeted between about 1.5 meters/second and about 3meters/second; wherein the one or more openings form an oblong shapesuch that the one or more streams of the viscous fluid that is ejectedfrom the holding chamber via the one or more openings form a sheet ofthe viscous fluid. In some embodiments, the one or more openings includetwo parallel slots with each slot having a length greater than a widthof the slot; wherein the method further includes detecting alignment ofthe length of the slots with the eye of the user; and wherein actuatingthe solenoid is in response to detecting the alignment of the length ofthe slots with the eye of the user.

The phrase “at least one of A and B” should be understood to mean “A, B,or both A and B.” The phrase “one or more of the following: A, B, and C”should be understood to mean “A, B, C, A and B, B and C, A and C, or allthree of A, B, and C.” The phrase “one or more of A, B, and C” should beunderstood to mean “A, B, C, A and B, B and C, A and C, or all three ofA, B, and C.”

Generally, any creation, storage, processing, and/or exchange of userdata associated with the method, apparatus, and/or system disclosedherein is configured to comply with a variety of privacy settings andsecurity protocols and prevailing data regulations, consistent withtreating confidentiality and integrity of user data as an importantmatter. For example, the apparatus and/or the system may include amodule that implements information security controls to comply with anumber of standards and/or other agreements. In some embodiments, themodule receives a privacy setting selection from the user and implementscontrols to comply with the selected privacy setting. In otherembodiments, the module identifies data that is considered sensitive,encrypts data according to any appropriate and well-known method in theart, replaces sensitive data with codes to pseudonymize the data, andotherwise ensures compliance with selected privacy settings and datasecurity requirements and regulations.

In several example embodiments, the elements and teachings of thevarious illustrative example embodiments may be combined in whole or inpart in some or all of the illustrative example embodiments. Inaddition, one or more of the elements and teachings of the variousillustrative example embodiments may be omitted, at least in part,and/or combined, at least in part, with one or more of the otherelements and teachings of the various illustrative embodiments.

The term “about,” as used herein, should generally be understood torefer to both numbers in a range of numerals. For example, “about 1 to2” should be understood as “about 1 to about 2.” Moreover, all numericalranges herein should be understood to include each whole integer, or1/10 of an integer, within the range.

Any spatial references such as, for example, “upper,” “lower,” “above,”“below,” “between,” “bottom,” “vertical,” “horizontal,” “angular,”“upwards,” “downwards,” “side-to-side,” “left-to-right,”“right-to-left,” “top-to-bottom,” “bottom-to-top,” “top,” “bottom,”“bottom-up,” “top-down,” etc., are for the purpose of illustration onlyand do not limit the specific orientation or location of the structuredescribed above.

In several example embodiments, while different steps, processes, andprocedures are described as appearing as distinct acts, one or more ofthe steps, one or more of the processes, and/or one or more of theprocedures may also be performed in different orders, simultaneously,and/or sequentially. In several example embodiments, the steps,processes and/or procedures may be merged into one or more steps,processes, and/or procedures.

In several example embodiments, one or more of the operational steps ineach embodiment may be omitted. Moreover, in some instances, somefeatures of the present disclosure may be employed without acorresponding use of the other features. Moreover, one or more of theabove-described embodiments and/or variations may be combined in wholeor in part with any one or more of the other above-described embodimentsand/or variations.

Although several example embodiments have been described in detailabove, the embodiments described are examples only and are not limiting,and those skilled in the art will readily appreciate that many othermodifications, changes, and/or substitutions are possible in the exampleembodiments without materially departing from the novel teachings andadvantages of the present disclosure. Accordingly, all suchmodifications, changes, and/or substitutions are intended to be includedwithin the scope of this disclosure as defined in the following claims.

In the claims, any means-plus-function clauses are intended to cover thestructures described herein as performing the recited function and notonly structural equivalents, but also equivalent structures. Moreover,it is the express intention of the applicant not to invoke 35 U.S.C. §112(f) for any limitations of any of the claims herein, except for thosein which the claim expressly uses the word “means” together with anassociated function.

What is claimed is:
 1. A fluid dispensing device, comprising: acartridge comprising a housing and a head coupled to the housing,wherein the housing forms a first chamber configured to accommodate afluid, and wherein the head comprises: a holding chamber in fluidcommunication with the first chamber and configured to accommodate aportion of the fluid prior to ejection; a moveable wall on a first sideof the holding chamber; and a nozzle on a second side of the holdingchamber opposite the moveable wall; wherein the nozzle forms one or moreopenings to eject the portion of the fluid from the holding chamber. 2.The device of claim 1, wherein the head is configured to be positionedin an actuator, wherein the actuator is movable between a loadedposition and a striking position; wherein, when in the loaded position,the actuator is spaced from the moveable wall; and wherein, when in thestriking position, the actuator has moved the moveable wall toward thenozzle to eject the portion of the fluid from the holding chamber viathe one or more openings.
 3. The device of claim 1, wherein thecartridge further comprises an actuatable cap, wherein the actuatablecap is configured to cover the nozzle in a closed position and isconfigured to uncover the nozzle in an open position, wherein the nozzleis in an open position when the fluid is dispensed from the nozzle. 4.The device of claim 3, wherein at least a portion of the actuatable capis at least partially transparent to ultraviolet (“UV”) light to allow,while in the actuatable cap is in the closed position, a portion of theUV light to illuminate the nozzle.
 5. The device of claim 1, wherein theone or more openings comprise one of: a plurality of parallel slots or aplurality of openings arranged linearly.
 6. The device of claim 1,wherein the one or more openings are arranged such that the portion ofthe fluid ejected has a width and a height, wherein the width is greaterthan or equal to the height.
 7. The device of claim 6, wherein the oneor more openings comprises a single oblong opening.
 8. The device ofclaim 1, wherein: the moveable wall is movable between a first positionrelative to the one or more openings and a second position relative tothe one or more openings; when in the first position, the moveable wallis spaced from the one or more openings; when in the second position,the moveable wall blocks the one or more openings; when moving themoveable wall from the first position to the second position ejects thefluid from the holding chamber; when in the second position, themoveable wall fluidically isolates the one or more openings from thefirst chamber; and when moving the moveable wall from the secondposition to the first position fluid is drawn from the first chamberinto the holding chamber.
 9. The device of claim 1, wherein the headforms an air entry port in fluid communication with the first chamberand further comprises a sterile air filter that is sealed to the headsuch that the sterile air filter filters the air passing through the airentry port, and wherein the sterile air filter is in the same plane asthe moveable wall such that it can be sealed while sealing the moveablewall.
 10. A fluid dispensing device, comprising: a cartridge comprising:a housing forming a first chamber configured to accommodate a fluid; anda head coupled to the housing, the head comprising: a holding chamber influid communication with the first chamber and configured to accommodatea portion of the fluid prior to ejection; a moveable wall on a firstpart of the holding chamber; and a nozzle on a second part of theholding chamber; and an applicator configured to accommodate thecartridge, wherein the applicator comprises an actuator movable betweena loaded position and a striking position, wherein, when the actuator isin the loaded position, the moveable wall is in a first positionrelative to the nozzle, and wherein, when the actuator is in thestriking position, the moveable wall is in a second position which iscloser to the nozzle than the first position.
 11. The device of claim10, wherein the applicator further comprises: a controller configured tocontrol the position of the actuator; and a blink detector that isoperably coupled to the controller, wherein the blink detector comprisesa sensor; wherein the sensor comprises a light-emitting diode to emitlight onto a surface of an eye of a user and photodiode to detectreflection of the light emitted onto the surface of the eye; andwherein, based on the light detected by the photodiode, the controllerdetermines whether the user has blinked the eye.
 12. The device of claim11, wherein the light detected by the photodiode is infrared.
 13. Thedevice of claim 10, wherein the applicator further comprises anultraviolet (“UV”) light emitting diode positioned such that the UVlight shines on at least a portion of the nozzle to sterilize a portionof the nozzle.
 14. The device of claim 10, wherein the applicatorfurther comprises a light source aligned with the nozzle, wherein thelight source is visible when the nozzle is correctly aligned towards theeye.
 15. The device of claim 10, wherein the one or more openingscomprise one of: two parallel slots or a plurality of openings arrangedlinearly.
 16. The device of claim 10, wherein, when in the firstposition, the moveable wall is spaced from the one or more openings;wherein, when in the second position, the moveable wall blocks the oneor more openings; wherein, when in the second position, the moveablewall fluidically isolates the one or more openings from the firstchamber; and wherein, when moving the moveable wall from the secondposition to the first position fluid is drawn from the first chamberinto the holding chamber.
 17. The device of claim 10, wherein the headforms an air entry port in fluid communication with the first chamberand further comprises a sterile air filter that is sealed to the headsuch that the sterile air filter filters the air passing through the airentry port, and wherein the sterile air filter is in the same plane asthe moveable wall such that it can be sealed while sealing the moveablewall.
 18. The device of claim 10, wherein the actuator comprises anelectromechanical solenoid.
 19. A method of dispensing a viscous fluidcomprising the steps of: providing a fluid dispenser comprising: acartridge comprising: a housing forming a first chamber configured toaccommodate a fluid; and a head coupled to the housing, the headcomprising: a holding chamber in fluid communication with the firstchamber and configured to accommodate a portion of the fluid prior toejection; a moveable wall on a first part of the holding chamber; and anozzle on a second part of the holding chamber opposite the moveablewall, wherein the nozzle forms one or more openings; and an applicatorsized to accommodate the cartridge, wherein the applicator comprises: anactuator; actuating the actuator to move the moveable wall therebycausing the portion of the fluid to be ejected from the holding chamberthrough the one or more openings of the nozzle.